Permeability and efflux transport of capecitabine and 5-FU in MDCKII-MDR1 or MDCKII-BCRP cells
| Compound | Assay | GF120918 | Pexact (× 10−6 cm/s) | Efflux Ratio | |
|---|---|---|---|---|---|
| A > B | B > A | ||||
| Capecitabine | MDCKII-MDR1 | No | 3.74 (2.52, 4.96) | 5.93 (6.51, 5.36) | 1.59 |
| Yes | 3.09 (3.32, 2.86) | 1.41 (1.10, 1.72) | 0.46 | ||
| MDCKII-BCRP | No | 3.53 ± 0.55 | 26.3 (24.2, 28.4) | 7.44 | |
| Yes | 4.21 (4.02, 4.41) | 2.96 (2.61, 3.30) | 0.70 | ||
| 5-FU | MDCKII-MDR1 | No | 0.99 ± 0.09 | 1.36 ± 0.04 | 1.38 |
| Yes | 1.08 ± 0.08 | 1.15 ± 0.03 | 1.06 | ||
| MDCKII-BCRP | No | 2.16 (1.20, 3.11) | 3.18 ± 0.62 | 1.47 | |
| Yes | 1.92 (1.75, 2.08) | 2.17 (2.90, 1.44) | 1.13 | ||
Data are presented as mean (individual value) or mean ± S.D.