TABLE 5

DDI indexes for OAT3 and OAT4 used to rank and predict the risk of the interaction between pemetrexed and different NSAIDs

Cmax values and unbound fractions were taken were taken from Goodman and Gilman (1941).

CompoundCmax[Iu] Unbound CmaxDDI Index OAT3 [Iu]/IC50DDI Index OAT4 [Iu]/IC50
μM
Ibuprofen155.11.550.380.042
Diclofenac6.30.030.010.012
Naproxen239.70.720.030.018
Celecoxib1.850.060.0040.003