TABLE 4

IC50 values of the inhibition of pemetrexed OAT-mediated uptake by different NSAIDs in OAT3 and OAT4 transfected HEK-PEAK cells

The results are expressed as mean (% coefficient of variation), n = 3.

InhibitorIC50
OAT3 MeanOAT3 Mean% CVOAT4 MeanOAT4 Mean(% CV)
μMμg/mlμMμg/ml
Ibuprofen4.150.8623.537.27.6745
Diclofenac3.70.76212.630.549.4
Naproxen27.95.7624398.0510.3
Celecoxib14.22.9345214.3318.4