Effect of the addition of OAT3 and OAT4 to the kidney model
Observed values are from Sweeney et al. (2006).
| Parameter | Observed Value | Predicted | ||
|---|---|---|---|---|
| Both OAT3 and OAT4 | No OAT3 | No OAT4 | ||
| Cmax (µg/ml) | 102.1 | 111.6 | 116.6 | 111.5 |
| AUC0–inf (µg/ml per hour) | 164.7 | 158 | 618.6 | 159.2 |
| CL plasma (l/h) | 5.6 | 5.7 | 1.48 | 5.8 |
| fe,0–24 | 0.8–0.9 | 1 | 0.7 | 0.3 |
| Maximum amount of drug in renal cells (mg) | NA | 0.01 | 0.01 | 667.2 |