TABLE 3

Comparison of GPIMR adducts and fragments of the protonated reference compounds and the M2 metabolite

GPIM ReagentsMS IonsNitrosobenzene
(1) Embedded ImagePyridine N-Oxide
(2) Embedded ImageTrimethylamine N-Oxide
(3) Embedded ImageN-Aryl Hydroxylamine
(4) Embedded ImageM1M2
Molecular ion [MH]+1089676166330330
DMDS
Embedded ImageAdduct ions[MH+31]+aNo adduct detected[MH+45]+[MH+31]+a[MH+45]+[MH+45]+
[MH+94]+[MH+45]+
TBP
Embedded ImageAdduct ions[MH+56]+a[MH+145]+aNo adduct detected[MH+145]+a[MH+145]+aNo adduct detected
[MH+146]+a[MH+146]+a[MH+220]+a
TDMAB
Embedded ImageAdduct ionsNo adduct detected[MH+98]+a[MH+98]+a[MH+98]+a[MH+98]+a[MH+98]+a
Fragmentation of adducts[MH+98]+a[MH+98]+aNo fragment[MH+98]+a[MH+98]+a
m/z 115a→NL116a→NL116a→NL116a
  • a Unique ions or fragmentations.