Pharmacokinetic parameters of valsartan after intravenous administration with and without rifampicin in SD rats
Valsartan was intravenously administered to SD rats at a dose of 0.5 mg/kg alone and in combination with 20 or 80 mg/kg intravenous rifampicin. Each value represents the mean ± S.D. (N = 3 for the rifampicin-administered groups; N = 6 for no inhibitor group).
| Inhibitor | AUC0–t | AUC0–∞ | CLt | Vd | Kp,liver | |
|---|---|---|---|---|---|---|
| Compound | Dose | |||||
| mg/kg | ng·h/ml | ng·h/ml | ml/h/kg | ml/kg | 1 hour | |
| — | — | 2013 ± 482 | 2025 ± 547 | 266 ± 90 | 359 ± 94 | 18 ± 10 |
| Rifampicin | 20 | 16,686 ± 330 | 16,781 ± 350 | 29.8 ± 0.6 | 96.8 ± 2.5 | 0.44 ± 0.07 |
| Rifampicin | 80 | 27,428 ± 6358 | 28,208 ± 6952 | 18.6 ± 5.2 | 104 ± 11 | 0.42 ± 0.06 |