TABLE 1

Intrinsic clearance of 2-ATBA in the liver microsomes and hepatocytes

Species	Microsomes		Hepatocytes
Species	Clearance	Scaled to %LBF^{^a}	Clearance	Scaled to %LBF^{^a}
	µl/min/mg		µl/min/10⁶ cells
Human	<4	<15	2.1	31
Rat	13	27	4.4	27
Dog	29	48	4.8	36
Cynomolgus monkey	8.4	22	1.8	14

↵^a Based on the Well-Stirred Model without plasma protein adjustment.
LBF, liver blood flow.