Precipitant | Therapeutic Class | Ki | IC50 | Reference |
---|---|---|---|---|
μM | ||||
Afatinib | Kinase inhibitors | – | 0.75 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/201292Orig1s000TOC.cfm |
Aripiprazole | Antipsychotics | – | 3.5 | Nagasaka et al., 2012 |
Axitinib | Kinase inhibitors | – | 4.4 | Reyner et al., 2013 |
Curcumin | Food products | – | 1.6 | Kusuhara et al., 2012 |
Cyclosporine | Immunosuppressants | 6.7 | 13.4a | Xia et al., 2007 |
Elacridar | Drug distribution modulators | – | 0.31 | Si et al., 2013 |
Erlotinib | Kinase inhibitors | 0.15 | 0.13 | Noguchi et al., 2009 |
Fluvastatin | HMG-CoA reductase inhibitors (statins) | 5.43 | 10.86a | Hirano et al., 2005 |
Fumitremorgin C | None | 0.55 | 0.25 | Noguchi et al., 2009 |
Gefitinib | Kinase inhibitors | – | 1.01 | Yanase et al., 2004 |
Ivermectin | Antiparasitics | 1.4 | 2.8a | Jani et al., 2011 |
Ko143 | Transporter modulators | – | 0.013 | Xia et al., 2007 |
Lapatinib | Kinase inhibitors | – | 0.025 | Polli et al., 2008 |
Nilotinib | Kinase inhibitors | 0.69 | 1.38a | Tiwari et al., 2009 |
Novobiocin | Antibiotics | – | 0.063 | Elsby et al., 2011 |
Pantoprazole | Proton pump inhibitors | – | 5.5 | Suzuki et al., 2009 |
Pitavastatin | HMG-CoA reductase inhibitors (statins) | 2.92 | 5.84a | Hirano et al., 2005 |
Ponatinib | Kinase inhibitors | – | 0.013 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203469Orig1s000TOC.cfm |
Quercetin | Food products | – | 0.6 | Saito et al., 2006 |
Quizartinib (AC220) | Kinase inhibitors | – | 0.5 | Bhullar et al., 2013 |
Rabeprazole | Proton pump inhibitors | – | 8.5 | Suzuki et al., 2009 |
Regorafenib | Kinase inhibitors | – | 0.0447 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203085Orig1s000TOC.cfm |
Rilpivirine | Nonnucleoside reverse transcriptase inhibitors | – | 1.5 | Weiss and Haefeli, 2013 |
Sulfasalazine | Nonsteroidal anti-inflammatory drugs | – | 0.46 | Elsby et al., 2011 |
Sunitinib | Kinase inhibitors | 0.32 | 0.64a | Kawahara et al., 2010 |
Tacrolimus | Immunosuppressants | – | 6 | Saito et al., 2006 |
Teriflunomide | Other immunomodulators | – | 0.146 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202992Orig1s000TOC.cfm |
Trametinib | Kinase inhibitors | – | 1.1 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/204114Orig1s000TOC.cfm |
Trifluoperazine | Antipsychotics | – | 7.56 | Pan et al., 2013 |
Vismodegib | Cancer treatments | – | 2.4 | http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203388Orig1s000TOC.cfm |
↵a IC50 value was calculated as 2 × Ki, assuming linearity.