Inhibition of creatinine transport by INCB039110 or by a reference inhibitor
IC50 values in μM, mean ± S.D.; N = 3.
| Transporter | INCB039110 | Reference Inhibitor | |
|---|---|---|---|
| OAT2 | 84 ± 30 | Indomethacin | 6.5 ± 1.1 |
| OCT2 | 5.8 ± 2.0 | Cimetidine | 17 ± 3.3 |
| OCT3 | 80 ± 28 | Quinidine | 150 ± 39 |
| MATE1/MATE2-K | 3.7 ± 1.9 | Cimetidine | 4.6 ± 2.2 |
| OAT2/OCT2/OCT3/MATE1/MATE2-K | 27 ± 7.0 | Cimetidine | 32 ± 7.1 |