TABLE 3
Experimentally derived parameters with dosing of preformed norverapamil at initial concentrations of approximately 1.5 and 5 μM
| Parameters | Intended and Measured Verapamil Concentrations at t = 0 (mM) | P value | |
|---|---|---|---|
| 1.5 μM [1.75 ± 0.07 (n = 4)] | 5 μM [5.16 ± 0.09 (n = 3)] | ||
(ml/min) | 11.2 ± 1.1 | 11.0 ± 1.0 | 0.857 |
(ml/min) | 0.554 ± 0.079 | 0.253 ± 0.013 | 0.001 a |
(ml/min) | 10.6 ± 1.1 | 10.8 ± 1.0 | 0.826 |
(ml/min) | 0.032 ± 0.004 | 0.044 ± 0.006 | 0.001 a |
(ml/min) | 10.6 ± 1.1 | 10.8 ± 1.0 | 0.826 |
| 0.883 ± 0.090 | 0.900 ± 0.081 | 0.796 |
| 0.117 ± 0.090 | 0.100 ± 0.081 | 0.823 |
| 0.0031 ± 0.0005 | 0.0041 ± 0.0007 | 0.107 |
-
↵ a Significant difference in norverapamil dosing groups (1.5 and 5 μM); P < 0.05.