TABLE 4

Reported and prediction results of F_G and observed and prediction results of F

Drug	F_G		CL_int,HLM^{^a}	F_{H,in vitro}^{^b}	F
			μl/min per pmol
	Predicted^{^c}	Reported^{^d}			Predicted^{^e}	Observed^{^f}
Alfentanil	0.72	0.60^{^a}	0.890	0.613	0.440	0.43
Alprazolam	0.99	0.99	NA	NC	NA	NA
Buspirone	0.51	0.22	1.84	0.629	0.321	0.039
Cisapride	0.56	0.55^{^a}	2.13	0.819	NA	NA
Cyclosporin	0.99	0.35	0.474	0.967	0.959	0.28
Felodipine	0.02	0.53	15.5	0.155	0.003	0.16
Lovastatin	0.04	0.09	35.4	0.154	0.006	0.05
Midazolam	0.36	0.48	3.75	0.476	0.169	0.41
Nifedipine	0.60	0.74	2.00	0.594	0.358	0.50
Nisoldipine	0.03	0.11^{^a}	53.1	0.547	0.017	0.04
Repaglinide	0.84	0.89^{^a}	0.737	0.913	0.771	0.60
Rifabutin	0.85	0.21^{^a}	0.514	0.436	0.371	0.20
Saquinavir	0.92	0.18^{^a}	51.3	0.090	0.083	0.07
Sildenafil	0.77	0.54^{^a}	1.07	0.742	0.574	0.40
Simvastatin	0.02	0.19	51.7	0.131	0.003	0.05
Trazodone	0.90	0.83^{^a}	0.370	0.881	0.796	0.79
Triazolam	0.98	0.45	NA	NC	NA	NA
Zolpidem	0.99	0.81	0.0850	0.956	0.949	0.72