P450s | Substrate (Concentration) | Metabolite | Probe Inhibitor (Concentration) | |
---|---|---|---|---|
μM | μM | |||
1A2 | Phenacetin (50 μM)a | Acetaminophen | α-naphthoflavone (0.1 μM) | |
2A6 | Coumarin (1 μM) | 7-hydroxycoumarin | Tryptamine (2 μM) | |
2B6 | Bupropion (5 μM) | 2-hydroxybupropion | Sertraline (1 μM) | |
2C8 | Paclitaxel (5 μM) | 6α-hydroxypaclitaxel | Quercetin (0.5 μM) | |
2C9 | Diclofenac (4 μM) | 4′-hydroxydiclofenac | Sulfaphenazole (0.5 μM) | |
Tolbutamide (70 μM)a | 4-hydroxytolbutamide | Sulfaphenazole (0.5 μM) | ||
2C19 | Mephenytoin (1 μM) | 4′-hydroxymephenytoin | Nootkatone (0.5 μM) | |
Oxyomeprazole (20μM)a | 5-hydroxyomeprazole | Ticlopidine (1.0 μM) | ||
2E1 | Chlorzoxazone (20 μM)a | 6-hydroxychlorzoxazone | Clomethiazole (10 μM) | |
3A4/5 | Midazolam (5 μM)a | 1′-hydroxymidazolam | Ketoconazole (0.05 μM) | |
4′hydroxymidazolam | ||||
Testosterone (75 μM)a | 6β-hydroxytestosterone | Ketoconazole (0.05 μM) |
↵a Cocktail substrate