TABLE 5

Noncompartmental pharmacokinetic parameters for DM and DXO in beagle dog plasma after a single i.v. dose of DM (n = 6), pretreated with GFA or sodium saline

Data are expressed as means ± S.D.

Pharmacokinetic ParametersSaline GroupGFA Group
DM
 Cmax (ng/ml)291.2 ± 66.4302.0 ± 126.4
 t1/2 (h)2.08 ± 0.202.16 ± 0.27
 MRT (h)2.27 ± 0.242.50 ± 0.49
 AUC0-τ (ng⋅h/ml)548.7 ± 128.8541.7 ± 64.7
 AUC0-∞ (ng⋅h/ml)556.8 ± 132.5551.4 ± 66.7
DXO
 Cmax (pg/ml)2500.6 ± 1585.5862.5 ± 569.5*
 Tmax (h)0.9 ± 0.71.1 ± 0.7
 t1/2 (h)7.67 ± 2.668.36 ± 2.78
 MRT (h)7.31 ± 2.589.47 ± 1.77
 AUC0-τ (pg⋅h/ml)9093.5 ± 3091.34609.4 ± 2388.3*
 AUC0-∞ (pg⋅h/ml)9433.8 ± 3149.14885.6 ± 2730.0*
  • AUC0-τ, AUC from time 0 to 36 h; AUC0-∞, AUC from time 0 to infinite.

  • * P < 0.05