In vivo pharmacokinetic profile and AUCi/AUC predictions using GFA as the inhibitor in human
| AUCi/AUCa | ||||||
|---|---|---|---|---|---|---|
| GFA | Experimental Data | Simcyp Prediction | Equation 5 Prediction | |||
| DMb | DXOb | DM | DXO | DM | DXO | |
| 4 mg/kg | ND | ND | 1.063 (1.028–1.096) | 0.583 | 5.31 | NA |
| 10 mg/kg | 0.99 | 0.518 | 1.061 (1.031–1.090) | 0.407 | 9.48 | NA |
NA, not available; ND, not determined.
↵a The Simcyp and eq. 5 estimated ratios of AUC in the absence (AUC) or presence of GFA inhibitor (AUCi) at the indicated GFA dose (milligrams per kilogram) were presented in comparison with the experimental data collected in beagle dogs.
↵b Experimental data from beagle dogs.