AUCi/AUCa | ||||||
---|---|---|---|---|---|---|
GFA | Experimental Data | Simcyp Prediction | Equation 5 Prediction | |||
DMb | DXOb | DM | DXO | DM | DXO | |
4 mg/kg | ND | ND | 1.063 (1.028–1.096) | 0.583 | 5.31 | NA |
10 mg/kg | 0.99 | 0.518 | 1.061 (1.031–1.090) | 0.407 | 9.48 | NA |
NA, not available; ND, not determined.
↵a The Simcyp and eq. 5 estimated ratios of AUC in the absence (AUC) or presence of GFA inhibitor (AUCi) at the indicated GFA dose (milligrams per kilogram) were presented in comparison with the experimental data collected in beagle dogs.
↵b Experimental data from beagle dogs.