PK parameter | Rat Treatment with Probenecid | |
---|---|---|
Not Treated | Treated | |
Heart data | ||
C5min (μM) | 4.18 ± 1.06 | 7.38 ± 1.49a |
AUC0–∞ (μM⋅h) | 1.16 ± 0.10 | 3.64 ± 0.50a |
t1/2 (h) | 0.235 ± 0.027 | 0.429 ± 0.138a |
MRT (h) | 0.353 ± 0.05 | 0.588 ± 0.115a |
Lung data | ||
C5min (μM) | 2.80 ± 0.29 | 4.25 ± 0.54a |
AUC0–∞ (μM⋅h) | 0.72 ± 0.09 | 2.05 ± 0.12a |
t1/2 (h) | 0.15 ± 0.00 | 0.32 ± 0.02a |
MRT (h) | 0.26 ± 0.01 | 0.50 ± 0.03a |
Brain data | ||
C5min (μM) | 0.212 ± 0.101 | 0.309 ± 0.068a |
AUC0–∞ (μM⋅h) | 0.0729 ± 0.0177 | 0.173 ± 0.055a |
t1/2 (h) | 0.223 ± 0.116 | 0.363 ± 0.077a |
MRT (h) | 0.343 ± 0.19 | 0.543 ± 0.091a |
Liver data | ||
C5min (μM) | 0.601 ± 0.298 | 1.35 ± 0.32a |
AUC0–∞ (μM⋅h) | 0.227 ± 0.143 | 0.644 ± 0.206a |
t1/2 (h) | 0.124 ± 0.025 | 0.293 ± 0.018a |
MRT (h) | 0.201 ± 0.065 | 0.442 ± 0.037a |
Kidney data | ||
C5min (μM) | 127 ± 18 | 68.0 ± 16.7a |
AUC0–∞ (μM⋅h) | 23.6 ± 3.2 | 26.5 ± 5.7 |
t1/2 (h) | 0.225 ± 0.032 | 0.286 ± 0.032a |
MRT (h) | 0.216 ± 0.012 | 0.378 ± 0.031a |
Plasma data | ||
C5min (μM) | 13.3 ± 2.5 | 28.3 ± 5.1a |
AUC0–∞ (μM⋅h) | 4.17 ± 0.62 | 12.6 ± 1.5a |
t1/2 (h) | 0.287 ± 0.057 | 0.396 ± 0.095a |
MRT (h) | 0.238 ± 0.020 | 0.416 ± 0.034a |
↵a P < 0.05 when compared with the rat group not treated with probenecid.