TABLE 2

Biliary excretion of SAC, NAc-SAC, SACS, and NAc-SACS in rats after oral and i.v. administration

Data represent mean ± S.D. of three rats.

CompoundaBiliary Excretion (% of Dose)b
SACNAc-SACSACSNAc-SACSTotal
SACi.v.0.51 ± 0.090.92 ± 0.470.01 ± 0.010.06 ± 0.041.5 ± 0.59
Oral0.45 ± 0.280.77 ± 0.58n.d.0.05 ± 0.031.3 ± 0.89
NAc-SACi.v.0.49 ± 0.140.72 ± 0.21n.d.0.08 ± 0.041.3 ± 0.34
SACSi.v.n.d.n.d.0.10 ± 0.020.21 ± 0.060.32 ± 0.07

  • n.d., not detected.

  • ↵a A single oral or i.v. dose (5 mg/kg) of SAC, NAc-SAC, and SACS was administered to bile duct-cannulated rats.

  • ↵b Amount (% of dose, on a molar basis) of SAC, NAc-SAC, SACS, and NAc-SACS excreted in bile for 24 hours postdose.