TABLE 1

Correlation coefficients between MPTP oxidation and probe drug oxidation activities in liver microsomes from 11 individual marmosets

Probe Reaction Activity	P450 Isoform or FMO^{^a}	Correlation Coefficient for Rates of Formation of MPTP Metabolites
Probe Reaction Activity	P450 Isoform or FMO^{^a}	PTP	MPTP N-Oxide	MPDP⁺	MPP⁺
7-Ethoxyresorufin O-deethylation	CYP1A	0.73^*	−0.77	0.52	0.56
Coumarin 7-hydroxylation	CYP2A	−0.16	−0.37	−0.17	−0.15
Paclitaxel 6α-hydroxylation	CYP2C	0.29	−0.64	0.62	0.57
Warfarin 7-hydroxylation	CYP2C	0.60	−0.79	0.68^*	0.70^*
S-Mephenytoin 4′-hydroxylation	CYP2C	0.30	−0.60	0.29	0.27
Bufuralol 1′-hydroxylation	CYP2D	0.77**	−0.40	0.38	0.47
Chlorzoxazone hydroxylation	CYP2E	−0.27	0.38	−0.45	−0.46
Midazolam 1′-hydroxylation	CYP3A	0.92***	−0.65	0.62	0.73^*
Benzydamine N-oxygenation	FMO	0.63	0.75^*	0.51	0.62

↵^a The P450 isoform or FMO mainly responsible for catalyzing the probe reactions.
↵* P < 0.05; **P < 0.01; ***P < 0.001.