TABLE 4

Urinary excretion of SAC, NAc-SAC, SACS, and NAc-SACS in dogs after oral and i.v. administration

Data represent mean ± S.D. of three dogs

CompoundaUrinary Excretion (% of Dose)b
SACNAc-SACSACSNAc-SACSTotal
SACi.v.0.32 ± 0.070.89 ± 0.181.6 ± 0.8712 ± 1.714 ± 2.3
Oral0.34 ± 0.190.91 ± 0.441.7 ± 1.410 ± 4.913 ± 6.7
NAc-SACi.v.0.49 ± 0.061.8 ± 0.541.8 ± 0.4712 ± 3.016 ± 3.6
SACSi.v.n.d.n.d.5.6 ± 2.322 ± 4.027 ± 4.3
NAc-SACSi.v.n.d.n.d.2.5 ± 1.182 ± 5.885 ± 4.7

  • n.d., not detected.

  • ↵a A single oral or i.v. dose (2 mg/kg) of SAC, NAc-SAC, SACS, and NAc-SACS was administered to dogs.

  • ↵b Amount (% of dose, on a molar basis) of SAC, NAc-SAC, SACS, and NAc-SACS excreted in urine for 48 hours postdose.