Summary of key PK parameters for intact NT and CT in rats and monkeys after a single s.c. dose
| Species | Dose | t1/2 | Tmax | Cmax | AUC0–t | AUC0–∞ | F% |
|---|---|---|---|---|---|---|---|
| mg/kg | h | h | µg/ml | µg⋅h/ml | µg⋅h/ml | ||
| Rats | |||||||
| Intact CT | 10 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. |
| Intact NT | 10 | 20.7 ± 6.07 | 30 ± 12 | 36.6 ± 14.9 | 1920 ± 794 | 1920 ± 794 | 68.3 |
| Monkeys | |||||||
| Intact CT | 1 | N.C. | 4.0 ± 2.3 | 1.32 ± 0.568 | 9.11 ± 4.63 | N.C. | 10.2 |
| Intact NT | 1 | 56.8 ± 6.88 | 6.0 ± 0.0 | 3.08 ± 1.02 | 222 ± 54.5 | 228 ± 53.7 | 58.3 |
AUC0–∞, area under concentration-time curve from 0 to infinity; AUC0–t, area under concentration-time curve from 0 to last measured time point; F%, bioavailability; N.C., not calculated due to insufficient data points; N.D., not determined because all concentrations were below limit of detection limit.