TABLE 4

In vitro inhibition of RIF of uptake of RSV (0.1µM) or ATV (0.01 µM) mediated by cOATP1B1, cOATP1B3, cOATP2B1, or cNTCP, and the risk for in vivo inhibition in cynomolgus monkeys

TransportersProbe Substrate RSV (0.1 µM)Probe Substrate ATV (0.01µM)
IC50R-valueIC50R-value
µMµM
cOATP1B10.25 ± 0.0364.50.14 ± 0.01114.3
cOATP1B31.3 ± 0.113.20.75 ± 0.0822.2
cOATP2B161.7 ± 3.61.2662.7 ± 10.71.25
cNTCP83.5 ± 7.61.1993.4 ± 10.41.17