Mouse, monkey, and human pH 6.0 FcRn binding affinities for PF-05231023 and the unconjugated IgG1κ scaffold of PF-05231023.
Data represent means ± S.D. from two to four experiments.
| Species | KD | |
|---|---|---|
| IgG1κ | PF-05231023 | |
| nM | ||
| Mouse | 2.5 ± 0.9 | 13 ± 3 |
| Monkey | 92 ± 18 | 1600 ± 200 |
| Human | 75 ± 17 | 2528 ± 11 |