TABLE 9

PK parameter estimates following a single dose of mAb A in cynomolgus monkeys from the subcolony with pre-existing ADA

Dose	Animal ID	C_max	T_max^{^a}	AUC_inf	V_z	CL	t_1/2
		μg/ml	days	μg·day/ml	ml/kg	ml/day/kg	days
1 mg/kg i.v.	705539^{^b}	13.65	–	187.62	107.92	5.33	14.04
	706541	21.94	–	N.D.	N.D.	N.D.	N.D.
	706549	19.94	–	N.D.	N.D.	N.D.	N.D.
	707625^{^b}	25.15	–	181.67	78.06	5.50	9.83
3 mg/kg i.v.	705609^{^b}	56.22	–	456.85	96.48	6.57	10.18
	706533	58.47	–	N.D.	N.D.	N.D.	N.D.
	706545^{^b}	55.45	–	456.58	105.31	6.57	11.11
	706565	56.72	–	N.D.	N.D.	N.D.	N.D.
10 mg/kg i.v.	706605	239.97	–	N.D.	N.D.	N.D.	N.D.
	707629	223.84	–	N.D.	N.D.	N.D.	N.D.
	709599	184.94	–	N.D.	N.D.	N.D.	N.D.
3 mg/kg s.c.	706535	26.40	3.00	N.D.	–	–	N.D.
	706559^{^b}	31.07	3.00	772.66	–	–	17.79
	706575^{^b}	23.85	3.00	499.19	–	–	12.22

N.D., not determined due to poorly defined terminal phase.
↵^a Median instead of mean ± S.D. is presented for the T_max.
↵^b The individual animal tested negative for ADAs to mAb A at the end of the study.