Prediction of the DDI potential of zafirlukast with UGT substrates by considering the maximum plasma concentration at the inlet to the liver and the concentrations in the small intestine
| Substrate | Hepatic Interaction | Intestinal Interaction | |||
|---|---|---|---|---|---|
| Ki (µM) | 1 + Iin,max/Ki | 1 + fu × Iin,max/Ki | Ki (µM) | 1 + Igut/Ki | |
| SN-38 | 1.2 | 5.4 | 1.01 | 1.9 | — |
| Furosemide | 2.4a | 3.2 | 1.02 | 1.5a | 192.3 |
| Etodolac | 4.4a | 2.2 | 1.02 | N.D. | — |
| S-Naproxen | 11.6a | 1.5 | 1.04 | N.D. | — |
| Diclofenac | 13.2a | 1.4 | 1.04 | 8.1a | 35.4 |
N.D., not determined.
↵a The Ki values were calculated using the following equation: Ki = 1/2 × IC50.