Comparison of predicted and observed mean human CL values for PF-05231023
Data represent the mean or mean ± S.D. Monkey and rat CL values for the intact NT and CT of FGF21 were scaled to human CL values using a fixed allometric exponent of 0.80.
| Scaling Method | Human CL | |
|---|---|---|
| NT | CT | |
| l/h | ||
| Rat single-species | 0.097 | 0.32 |
| Monkey single-species | 0.12 | 0.55 |
| Two-species | 0.15 | 1.1 |
| Observed human | 0.070 ± 0.019 | 0.49 ± 0.26 |