TABLE 1

Physiologic parameters associated with the physiologically based pharmacokinetic model

Tissue	Total Tissue Volume (V_tot)^{^a}	Interstitial Volume (V_isf)^{^a}	Lymphatic Flow Rate (L_tis)^{^b}	Residual Plasma Volume (% V_res/V_tot)^{^c}
	ml		ml/h
Lung	1.4	0.263	0.8291	6
Liver	15.7	2.56	0.2307	3
Kidney	2.41	0.361	0.1028	3
Spleen	2.77	0.554	0.0504	6
Heart	1.02	0.146	0.0425	3
Muscle	122	15.8	0.2604	1.5
Adipose	33.1	5.63	0.0631	1.5
Paw	0.5^{^d}	0.075^{^d}	Estimated	1.5
Skin	49.9	16.5	0.0563	1.5
Carcass		6.75	0.224	1.5
Plasma	9.06
Lymph	16.47
Total		48.71	1.86

↵^a Physiologic parameter values obtained from (Shah and Betts, 2012).
↵^b Lymphatic flow rate in each tissue is estimated as the product of the relative ratio of the blood flow of that tissue (Shah and Betts, 2012) and the total lymphatic flow rate. Liver blood flow is assumed to be the sum of blood flows in the liver, spleen, small intestine, and pancreas. Total lymphatic flow rate is allometrically scaled from human (2.9 l/day) with exponent factor 0.74.
↵^c Average value of literature reports (Bernareggi and Rowland, 1991; Baxter et al., 1994; Garg, 2007).
↵^d Assuming interstitial space accounts for 15% of total tissue volume.