Compound | RSV i.v. | RSV PO | ||||
---|---|---|---|---|---|---|
Control | RIF PO | Ratio | Control | RIF PO | Ratio | |
RSV | ||||||
CLtotal (l/h/kg) | 1.17 ± 0.17 | 0.42 ± 0.03a | 0.36 | |||
Vss(l/kg) | 1.56 ± 0.27 | 1.11 ± 0.24 | 0.71 | |||
t1/2 (h) | 2.93 ± 0.88 | 5.85 ± 1.48 | 1.99 | 12.99 ± 3.68 | 9.36 ± 2.08 | 0.72 |
AUC0–last (h⋅µM) | 1.80 ± 0.23 | 4.77 ± 0.44a | 2.65 | 0.39 ± 0.21 | 2.39 ± 0.54a | 6.05 |
AUCinf (h⋅µM) | 1.88 ± 0.24 | 4.99 ± 0.40a | 2.66 | 0.56 ± 0.27 | 2.72 ± 0.55a | 4.85 |
Cmax (µM) | 0.04 ± 0.02 | 0.45 ± 0.11a | 10.30 | |||
Tmax (h) | 4.27 ± 0.63 | 1.25 ± 0.40a | 0.29 | |||
Fh | 0.27 | 0.74 | 2.70 | |||
F | 0.10 | 0.48 | 4.85 | |||
FaFg | 0.36 | 0.66 | 1.80 | |||
RSV lactone | ||||||
T1/2 (h) | 1.62 ± 0.11 | 1.38 ± 0.09 | 0.85 | 14.29 ± 2.69 | 6.98 ± 1.10a | 0.49 |
AUC0–last (h⋅µM) | 1.43 ± 0.23 | 3.10 ± 0.31a | 2.16 | 1.39 ± 0.45 | 6.33 ± 2.76 | 4.56 |
AUCinf (h⋅µM) | 1.50 ± 0.23 | 3.16 ± 0.29a | 2.11 | 2.23 ± 0.93 | 8.17 ± 3.11 | 3.67 |
Cmax (µM) | 1.03 ± 0.33 | 3.05 ± 0.31a | 2.96 | 0.11 ± 0.03 | 0.83 ± 0.25a | 7.72 |
Tmax (h) | 0.25 ± 0.00 | 0.25 ± 0.00 | 1.00 | 5.00 ± 0.82 | 2.50 ± 0.96a | 0.50 |
↵a Significantly different from control group (P < 0.05).