TABLE 2

Plasma and tissue AUC values and ratios for healthy and CIA rats

Tissue	AUC_{0–264 h}		Tissue/Plasma AUC Ratio
Tissue	Healthy (SD)^{^a}	CIA (SD)^{^a}	Healthy	CIA
	μg/ml • h
Lung	285.6 (39.0)	248.3 (52.2)	0.1290	0.1490
Liver	110.1 (32.4)	135.7 (29.5)	0.0487	0.0939
Kidney^{^b}	177.1 (19.5)	334.7 (55.2)	0.0783	0.2320
Spleen	172.4 (35.8)	121.2 (20.1)	0.0762	0.0838
Heart	207.1 (34.4)	111.4 (19.7)	0.0916	0.0771
Muscle	80.9 (12.7)	88.3 (24.8)	0.0358	0.0611
Adipose	88.5 (20.3)	87.9 (34.7)	0.0391	0.0608
Paw	148.6 (21.8)	338.6 (82.9)	0.0657	0.2340
Blister fluid	970.2 (293.7)	1006.6 (412.3)	0.4290	0.6960
Plasma	2260.9 (213.6)	1445.2 (370.6)

↵^a SD of AUC_{0–264 h} was calculated using NCA with sparse sampling using WinNonlin 6.1 (Nedelman and Jia, 1998; Holder, 2001).
↵^b Concentrations of etanercept in kidney used for calculation of AUC are subject to poor data quality.