Depletion half-lives of steroid hormones when incubated with HepaRG cells or SCHH
| Hormone | HepaRG Cell | SCHH | |||
|---|---|---|---|---|---|
| Concentration | Half-Life | Concentration | Half-Life | ||
| nM | Hours | nM | Hours | ||
| Estradiol | 1× | 51 | NQ | 319 | 2.0 ± 0.5* |
| 10× | 510 | 3.3 ± 0.7 | 3187 | 1.6 ± 0.4* | |
| Progesterone | 1× | 395 | 7.5 ± 1.0 | 705 | 1.4 ± 0.4* |
| 10× | 3950 | 9.2 ± 0.7 | 19,100 | 1.6 ± 1.0* | |
| Cortisol | Unbound | 16.3 | 13.0 ± 2.4* | 48.8 | NQ |
| 1× | 798 | ND | 798 | ND | |
| 10× | 7980 | ND | 7980 | ND | |
ND, no depletion; NQ, not quantified; data expressed as mean ± S.D.; *, n = 3.