Species/PK Assays | CL | Vc | Vss | t1/2 | Cmax/Dose | AUC0–t/Dose | AUC0–∞/Dose |
---|---|---|---|---|---|---|---|
ml/h per kg | ml/kg | ml/kg | h | µg/ml | µg⋅h/ml | µg⋅h/ml | |
Rats | |||||||
Intact CT | 11.7 ± 0.33 | 29.6 ± 2.45 | 38.0 ± 2.90 | 6.30 ± 0.085 | 30.4 ± 2.57 | 85.5 ± 2.30 | 85.7 ± 2.30 |
Intact NT | 3.59 ± 0.373 | 35.5 ± 13.6 | 70.9 ± 16.9 | 22.7 ± 2.16 | 30.3 ± 1.01 | 280 ± 26.6 | 281 ± 26.4 |
Total FGF21 | 2.11 | 51.9 | 111 | 97.3 | 18.5 | 466 | 474 |
Total IgG | 1.29 | 30.2 | 199 | 286 | 20.5 | 699 | 775 |
Monkeys | |||||||
Intact CT | 12.1 ± 4.19 | 41.3 ± 4.18 | 37.8 ± 3.17 | 3.02 ± 1.36 | 22.2 ± 1.99 | 88.4 ± 27.3 | 89.7 ± 28.0 |
Intact NT | 2.61 ± 0.421 | 41.5 ± 4.52 | 103 ± 7.39 | 59.8 ± 8.53 | 23.4 ± 1.91 | 386 ± 57.6 | 391 ± 58.0 |
Total FGF21 | 2.34 | 38.1 | 102 | 82.0 | 25.7 | 427 | 429 |
Total IgG | 1.48 | 37.0 | 230 | 209 | 26.2 | 620 | 678 |
AUC0–∞, area under concentration-time curve from 0 to infinity; AUC0–t, area under concentration-time curve from 0 to the last measured time point; Vc, central distribution volume.