Control | Poly(I:C) | |
---|---|---|
λz(1/min)a | 0.0076 | 0.0080 |
Co (ng/ml)a | 6199 | 17,329 |
AUC0-INF (min*ng/ml)a | 220,085 | 482,860 |
CL (ml/min/kg)a | 45 | 21 |
Vss (ml/kg)a | 4567 | 1803 |
fu, plasma (%)b | 0.85 ± 0.33 | 0.10 ± 0.01* |
λz, first-order elimination rate constant, ke; AUC0-INF, (from zero to infinite time); Co, concentration at time zero; CL, clearance; fu,plasma, fraction unbound; Vss, volume of distribution.
↵a Predicted values calculated by noncompartmental analysis (Phoenix WinNonlin).
↵b Percentage unbound LPV (mean ± S.E.) calculated as described in Materials and Methods.
↵* P < 0.05 (significantly different from controls)