Parameter | 1 mg/kg i.v. Naive | 10 mg/kg i.v. Bile-Duct Cannulated |
---|---|---|
CL (mL/min/kg) | 96.2 ± 16.3 | 73.7 ± 13.6 |
CLrenal (mL/min/kg) | nd | 1.51 ± 0.906 |
CLbile (mL/min/kg) | nd | 0.050 ± 0.029 |
Vss (L/kg) | 7.93 ± 1.44 | 8.10 ± 2.12 |
AUC0–8h (h × ng/mL) | 174 ± 31.3 | 2295 ± 418 |
AUC0-inf (h × ng/mL) | 177 ± 32.1 | 2313 ± 420 |
MRT (h) | 1.38 ± 0.191 | 1.83 ± 0.319 |
MRT, mean residence time; nd, not determined.