Summary of urine excretion and renal clearance data of remogliflozin and GSK279782
Values are the geometric mean (%CV) for each parameter.
| Analyte | Mild Renal Impairment (N = 12) | Normal Match for Mild Impairment (N = 8) | Moderate Renal Impairment (N = 7) | Normal Match for Moderate Impairment (N = 7) |
|---|---|---|---|---|
| Ae(0-24) (mg) | ||||
| Remogliflozin | 9.89 (45) | 14.4 (24) | 6.45 (66) | 15.8 (20) |
| GSK279782 | 2.20 (99) | 2.99 (63) | 1.55 (91) | 4.61 (48) |
| Percentage dose recovered (%) | ||||
| Remogliflozin | 4.85 (45) | 7.06 (24) | 3.16 (66) | 7.75 (20) |
| GSK279782 | 1.19 (99) | 1.62 (63) | 0.84 (91) | 2.49 (48) |
| CLr (ml/min) | ||||
| Remogliflozin | 76.9 (49) | 122 (28) | 41.5 (43) | 116 (21) |
| GSK279782 | 56.3 (72) | 107 (28) | 26.0 (68) | 103 (16) |
| CLr,u (ml/min) | ||||
| Remogliflozin | 25.0 (46) | 39.7 (32) | 13.2 (43) | 37.6 (27) |
| GSK279782 | 24.0 (69) | 44.3 (24) | 10.6 (69) | 41.8 (16) |
Ae(0-24), amount excreted from 0 to 24 hours; CLr, renal clearance; CLr,u, renal clearance corrected for unbound fraction.