TABLE 1

Estimation of f_BCL_int and CL_int for data from Mehvar et al. (1994)

	C_in (μM)	C_out (μM)	F^{^a}	CL = Q × E	f_P^{^a}	f_P CL_int^a	CL_int^{^b}	f_BCL_int(cal) = (1/F − 1) × Q^{^c}	B:P^{^d}	f_B = f_P/(B:P)	CL_int(cal)
	ng/ml (μM)	ng/ml (μM)		ml/min		ml/min	ml/min				ml/min
S-VER	580 (1.28)	35 (0.077)	0.0603	14.1	0.12	260	2200	234	0.76	0.16	1475
R-VER	540 (1.19)	16 (0.035)	0.0296	14.6	0.22	430	1900	491	0.66	0.33	1474

CL, clearance.
↵^a Data reported by Mehvar et al. (1994).
↵^b CL_int based on f_P CL_int/f_P, which is also reported by Mehvar et al. (1994).
↵^c f_BCL_int(cal) based on our recalculation with the equation, according to the well stirred model (Pang and Rowland, 1977).
↵^d From Robinson and Mehvar (1996) for low VER concentrations.