TABLE 4

Observed ISF, unbound plasma, unbound brain, and CSF concentrations at 6 hours after cassette and discrete dosing of eight compounds

Data are presented as the mean ± S.D. (n = 4).

Compound	Cassette				Discrete
Compound	C_ISF	C_up	C_ub	C_CSF	C_ISF	C_up	C_ub	C_CSF
Carbamazepine	117 ± 62	420 ± 142	41.8 ± 15.5	176 ± 30	62.9 ± 34.4	144 ± 47	16.0 ± 3.3	238 ± 122
Citalopram	23.6 ± 10.7	92.5 ± 10.3	8.45 ± 1.02	30.6 ± 5.8	38.1 ± 1.1	44.5 ± 24.2	37.2 ± 8.8	45.8 ± 25.5
Desmethylclozapine	4.25 ± 2.32	37.4 ± 5.6	1.56 ± 0.11	8.29 ± 5.63	4.55 ± 1.56	30.8 ± 6.9	2.27 ± 0.35	8.51 ± 0.90
Diphenhydramine	31.2 ± 5.2	44.4 ± 3.8	12.2 ± 1.1	26.0 ± 5.4	23.9 ± 5.0	22.6 ± 5.7	12.0 ± 4.7	34.3 ± 10.9
Gabapentin	51.7 ± 16.6	1250 ± 86	130 ± 12	169 ± 25	43.4 ± 6.3	2290 ± 532	99.3 ± 19.2	138 ± 43
Metoclopramide	28.8 ± 9.2	158 ± 16	10.7 ± 2.4	96 ± 27	9.46 ± 2.53	49.8 ± 10.8	6.49 ± 1.61	84.8 ± 31.7
Naltrexone	26.2 ± 8.3	46.6 ± 3.8	16.4 ± 2.6	79.2 ± 1.2	32.7 ± 2.0	56.3 ± 5.2	9.08 ± 1.06	149 ± 21
Stavudine	5.32^{^a}	376 ± 21	9.24^{^a}	BLLQ	BLLQ	128 ± 18	6.59 ± 1.35	BLLQ

BLLQ, below the low limit of quantitation; C_CSF, concentration in cerebrospinal fluid; C_ISF, interstitial fluid concentration measured by brain microdialysis; C_ub, unbound brain concentration measured by the brain homogenate method; C_up, unbound plasma concentration.
↵^a n = 2. S.D. was not calculated.