CISF/Cup, CISF/Cub, and CISF/CCSF measured from cassette and discrete methods
Data are presented as the mean ± S.D. (n = 4).
| Compound | Cassette | Discrete | Cassette/ Discrete Ratios | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CISF/Cup | CISF/Cub | CISF/CCSF | CISF/Cup | CISF/Cub | CISF/CCSF | CISF/Cup | CISF/Cub | CISF/CCSF | |
| Carbamazepine | 0.27 ± 0.08 | 2.8 ± 0.9 | 0.70 ± 0.45 | 0.42 ± 0.13 | 3.8 ± 1.4 | 0.35 ± 0.23 | 0.64 | 0.74 | 2.0 |
| Citalopram | 0.26 ± 0.12 | 2.8 ± 1.0 | 0.76 ± 0.28 | 1.0 ± 0.4 | 1.1 ± 0.2 | 0.98 ± 0.34 | 0.25 | 2.6 | 0.8 |
| Desmethylclozapine | 0.11 ± 0.04 | 2.2 ± 1.1 | 0.52 ± 0.28 | 0.075 ± 0.053 | 1.9 ± 0.6 | 0.53 ± 0.15 | 1.5 | 1.2 | 1.0 |
| Diphenhydramine | 0.71 ± 0.17 | 2.6 ± 0.6 | 1.3 ± 0.3 | 0.96 ± 0.32 | 3.4 ± 2.1 | 0.79 ± 0.45 | 0.74 | 0.78 | 1.6 |
| Gabapentin | 0.035 ± 0.011 | 0.43 ± 0.17 | 0.31 ± 0.12 | 0.021 ± 0.005 | 0.49 ± 0.09 | 0.34 ± 0.12 | 1.7 | 0.87 | 0.9 |
| Metoclopramide | 0.13 ± 0.10 | 2.1 ± 1.5 | 0.32 ± 0.036 | 0.20 ± 0.07 | 1.6 ± 0.6 | 0.13 ± 0.06 | 0.65 | 1.3 | 2.5 |
| Naltrexone | 0.57 ± 0.21 | 1.6 ± 0.5 | 0.35 ± 0.11 | 0.61 ± 0.03 | 3.7 ± 0.3 | 0.22 ± 0.02 | 0.95 | 0.45 | 1.6 |
| Stavudine | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Mean | NC | NC | NC | NC | NC | NC | 0.92 | 1.1 | 1.5 |
| S.D. | NC | NC | NC | NC | NC | NC | 0.51 | 0.7 | 0.6 |
NA, not available; NC, not calculated.