Mean total (±S.D.) recovery of radioactivity in feces, urine and bile from bile duct-intact (BDI) and bile duct-cannulated (BDC) rats and dogs administered a single oral dose of 14C-cabozantinib
| Species | Groupa | %Total Recovery | % Dose in Feces | % Dose in Urine | % Dose in Bile | % Dose in Cage Rinse |
|---|---|---|---|---|---|---|
| Rat | BDI | 92.5 ± 1.30 | 84.6 ± 4.65 | 2.44 ± 0.261 | N.A. | 0.880 ± 0.203 |
| BDC | 91.6 ± 1.89 | 45.8 ± 6.95 | 7.44 ± 4.63 | 29.1 ± 5.48 | 1.69 ± 1.06 | |
| Dog | BDI | 92.6 ± 1.08 | 86.2 ± 4.37 | 1.88 ± 1.39 | N.A. | 1.91 ± 1.33 |
| BDC | 91.7 ± 4.29 | 73.3 ± 4.96 | 0.679 ± 0.264 | 14.5 ± 7.71 | 1.10 ± 1.28 |
N.A., not applicable.
↵a BDI (n = 3) and BDC (n = 6) rats received a single dose via gavage (5 ml/kg) of cabozantinib (50 mg/kg) containing 14C-cabozantinib (750 µCi/kg); BDI (n = 3) and BDC (n = 3) dogs received a single dose via gavage (5 ml/kg) of cabozantinib (100 mg/kg) containing 14C-cabozantinib (25 µCi/kg); data reflect mean (±S.D.) radioactivity recoveries in matrices through 120 hours (rats) and 168 hours (dogs) postdose.