TABLE 3

Effects of full and partial activation of FMOs with and without the coenzyme NADPH on BZD and CLZ metabolism in HLM

Substrate	NADPH	N-Oxidation^a	N-Demethylation^a
100 μM	1 mM	pmol/mg protein per minute	pmol/mg protein per minute
BZD	+	498.4 ± 15.2
BZD	–	247.5 ± 17.4*
CLZ	+	682.6 ± 7.8	393.0 ± 7.7
CLZ	–	664.4 ± 13.5	400.1 ± 9.7

↵^a The data are expressed as mean ± S.E.M. (n = 3) and analyzed using two-sided Student’s t test. *P < 0.05 versus NADPH (+) with the same substrate.