TABLE 2

Kinetic effects of liquiritigenin on clozapine metabolism in HLM^a

Variables	Unit	Control	Liquiritigenin (0.2 mM)
NorCLZ
V_max	pmol/min per milligram of protein	584.9 ± 49.4	481.9 ± 62.8
K_m	μM	43.7 ± 14.3	57.2 ± 34.7
C_int	μl/min per milligram of protein	16.0 ± 4.2	15.2 ± 6.1
CLZ-N-oxide
V_max	pmol/min per milligram of protein	920.7 ± 48.1	605.9 ± 14.2^*
K_m	μM	46.3 ± 10.7	18.1 ± 3.7
C_int	μl/min per milligram of protein	21.5 ± 3.5	36.7 ± 7.7

↵^a Data are expressed as mean ± S.E.M. (n = 3) and analyzed using two-sided Student’s t test.
↵* P < 0.05 versus control.