TABLE 1

Production of chimeric mice using two different donors and two different host mice

Data of body weight and hAlb at 12 weeks old are shown as mean ± S.D.

Donor	Host Mouse	No. of Transplanted Cells/Mouse	Sex  of Host Mouse	No. of Transplanted Mice	No. of Dead Mice until 12 Weeks Old	No. of Mice  at 12 Weeks Old^a	Body Weight  at 12 Weeks Old	hAlb  at 12 Weeks Old	Portion of Chimeric Mice with RI > 70%
		×10⁵ cells					grams	mg/ml	%
BD85	Cyp3aKO/uPA/SCID	2.5	Male	8	0	8	16.7 ± 3.6	4.0 ± 3.1	15.0
		2.5	Female	12	1	11	14.3 ± 2.3	3.2 ± 2.7	15.0
		3.5	Male	6	1	3	14.8 ± 0.8	8.5 ± 6.3	53.3
		3.5	Female	9	2	5	13.4 ± 2.2	8.5 ± 3.7	53.3
		5.0	Male	22	2	20	14.7 ± 2.9	11.7 ± 2.7	77.8
		5.0	Female	23	0	22	12.6 ± 2.5	8.9 ± 5.4	77.8
	uPA/SCID	2.5	Male	212	23	158	16.3 ± 3.1	10.0 ± 3.0	72.9
	uPA/SCID	2.5	Female	43	1	39	15.7 ± 2.5	8.6 ± 2.7	72.9
BD195	Cyp3aKO/uPA/SCID	2.5	Male	110	4	57	18.1 ± 2.6	8.1 ± 4.0	65.1
		2.5	Female	19	0	18	16.5 ± 1.9	6.9 ± 3.0	65.1
		3.0	Male	23	0	23	15.3 ± 2.7	10.6 ± 2.8	82.6

↵^a Number of mice that were alive and unused for other studies at 12 weeks old.
Data of body weight and hAlb at 12 weeks old are shown as mean 6 S.D.