Resulting t1/2 (h) and kdeg–hr values from individual donors and the combined average and standard deviations using the monoexponential decay equation
| Parameter | Donor 1 | Donor 2 | Donor 3 | Donor 4 | Donor 5 |
|---|---|---|---|---|---|
| t1/2 (h) | 32.2 | 38.9 | 32.3 | 21.9 | 25.2 |
| CYP3A kdeg–hr | 0.0215 | 0.0178 | 0.0215 | 0.0316 | 0.0275 |
| R2 | 0.900 | 0.954 | 0.889 | 0.949 | 0.975 |
| CYP3A average t1/2 (h) (all donors) | 28.9 | ||||
| CYP3A t1/2 (h) standard deviation | 6.7 | ||||
| CYP3A average kdeg–h | 0.0240 ± 0.005 | ||||
| CYP3A4 average (excluding donor 2) | 27.2 | ||||
| CYP3A4 standard deviation | 5.2 | ||||
| CYP3A4 kdeg–h | 0.0255 ± 0.005 | ||||