TABLE 4

Published encapsulation efficiencies of various liposomal-antibiotic formulations

Drug Name	Lipid	Drug Input	Loading Efficiency	Milligrams Loaded	mg/μM	Citation
	μM	mg	%
Doxycycline	90 LEC anionic	2	49.17	0.98	0.01	Sangaré et al., 1998,
	90 LEC cationic	2	28.68	0.57	0.006	Sangaré
	90 LEC neutral	2	21.06	0.42	0.004	Sangaré et al., 1998
Doxycycline	90 LEC anionic	2	49.1	0.98	0.01	Sangaré et al., 1999
	90 LEC cationic	2	28.68	0.57	0.006	Sangaré et al., 1999
	90 LEC neutral	2	21	0.42	0.004	Sangaré et al., 1999
Doxycycline	90 LEC cationic	2	28.68	0.57	0.006	Sangaré et al., 2001a
Doxycycline	2.73 DPPC, phosphate	0.1354	15.98 (pH 6)	0.02	0.007	Budai et al., 2009, 2009
			16.18 (pH 7)	0.02	0.008
			16.29 (pH 8)	0.02	0.008
Doxycycline	2.73 DPPC, glucose	0.1354	24.28 (pH 6)	0.03	0.01	Budai et al., 2009
			28.31 (pH 7)	0.04	0.01
			21.2 (pH 8)	0.03	0.01
Doxycycline	2.73 DPPC mannitol	0.1354	39.47 (pH 6)	0.05	0.02	Budai et al., 2009
			30.36 (pH 7)	0.04	0.01
			39.47 (pH 8)	0.05	0.02
Doxycycline	20 DPPC	8.25	97.77	8.06	0.403	Current study
Doxycycline	80 sphing	33	43.87	14.47	0.18	Current study