TABLE 1

Demographics for hepatocyte donors used in the HepatoPac model

Demographics	Donor 1	Donor 2^{^a}	Donor 3^{^b}	Donor 4^{^c}	Donor 5^{^d}
Gender	Female	Male	Female	Female	Male
Age	19	56	54	61	31
Race/Ethnicity	Caucasian	African American	Caucasian	Not provided	Caucasian
Cause of death	Intracerebral bleed secondary to Intracranial hemorrhage/stroke	Cerebrovascular accident	Anoxia secondary to cerebrovascular accident	Not provided	Anoxia, secondary to heroin overdose
Medical history	Lupus	Diabetes, hypertension, kidney disease, insulin	Diabetes and hypertension, 3 years, med compliant	Not provided	Asthma: allergy-induced
Social history	No alcohol, tobacco, or drug use	No alcohol, tobacco, or drug use	Nonsmoker, social drinker	Not provided	Ethanol, tobacco, marijuana, oxycontin, heroin

↵^a This donor was determined through genotyping analysis to be CYP3A5 *1*3.
↵^b This donor was determined through genotyping analysis to be CYP3A5 *3*3.
↵^c This donor was designated as RTM by the manufacturer.
↵^d This donor was designated as donor 1307 by the manufacturer and was determined through genotyping analysis to be CYP3A5 *3*3.