Enzyme Source | R4G | R6G | ||||
---|---|---|---|---|---|---|
Km | Vmax | CLint | Km | Vmax | CLint | |
µM | pmol/min per mg | µl/min per mg | µM | pmol/min per mg | µl/min per mg | |
HIMs | 0.81 ± 0.11 | 750 ± 22 | 930 | 0.84 ± 0.14 | 78 ± 2.9 | 93 |
HLMs | 3.0 ± 0.73 | 850 ± 53 | 290 | 6.5 ± 0.73 | 310 ± 9.7 | 48 |
UGT1A1 | 4.3 ± 0.51 | 88 ± 2.7 | 20 | 3.6 ± 0.39 | 92 ± 2.4 | 26 |
UGT1A8 | 5.5 ± 0.48 | 550 ± 14 | 100 | 1.5 ± 0.17 | 110 ± 2.9 | 73 |
UGT1A10 | 0.87 ± 0.08 | 1100 ± 28 | 1260 | 0.96 ± 0.08 | 130 ± 3.1 | 140 |