TABLE 4

Mean pharmacokinetic parameters of CDP323 and CT7758 after single oral dosing of CDP323 (n = 3/sampling time) given as a suspension

Species	Oral Dose of CDP323 (mg/kg)	Pharmacokinetic Parameters of
		CT7758				CDP323
		C_max	AUC_0-∞	T_max	F^b	AUC_0-t
		µg/ml	µg.h/ml	hour	%	µg.h/ml
Mouse ^a	50	1.28	3.07	1	29	N.D.
	150	3.24	8.29	0.5	26	0.06
	500	11.1	59.9	1	57	0.50
Rat	25	1.31	2.78	0.5	27	N.D.
Dog ^a	10	4.8	18.8	1.5	12	0.03
	50	14.6	64.4	1.5	8.1	0.22
	200	20.5	162	3	5.1	2.1
Monkey	50	0.0447	0.228	1.5	<1	N.D.

↵^a Mean of 3 males and 3 females combined.
↵^b Oral bioavailability values are based on CT7758 only and used exposure data after 3 mg/kg i.v. CT7758 as detailed in Table 1 (i.e., assumed linear PK after intravenous).
N.D., not detected.