TABLE 3

In vitro metabolic and uptake clearance in mouse, rat, dog, and human hepatocytes and their scaled hepatic clearance according to Materials and Methods

Species	In Vitro Clearance	CLint	fu	B/P	Scaled Hepatic Clearance
		µl/min/10⁶hep			ml/min/kg
Mouse	Metabolic	NP	0.024	0.8	NP
	Uptake	2000	0.024	0.8	62
Rat	Metabolic	7.2	0.01	0.6	0.2
	Uptake	5274	0.01	0.6	40
Dog	Metabolic	<1	0.01	0.44	<0.02
	Uptake	702	0.01	0.44	8.3
Human	Metabolic	<1	0.01	0.6	<0.02
	Uptake	1160	0.01	0.6	7.4

NP, not performed.