TABLE 3

Estimation of the CD 6168 formation levels in vivo from in vitro anaerobic fecal incubations in rats and humans

Species	Rate of Formation	Estimated Formation of CD 6168 Based on In Vitro data^{^a}	For Comparison (In Vivo)
Species	Rate of Formation	Estimated Formation of CD 6168 Based on In Vitro data^{^a}	Deleobuvir Dose	Amount of CD 6168 Formed
	nmol/min per g	mg	mg	mg
Rat	3.18 ± 2.05^{^b}	2.18 ± 1.40	3.6	1.5
Human	1.95 (subject I)	202 (subject I)	800	280^{^c}
Human	0.184 (subject II)	19.1 (subject II)	800	280^{^c}