CYP Isoform | Thiol Isomer | Incubation Time | Km | Vmax | na | CLint, in vitro | Enzyme Abundance | CLint, expressed P450 | fmP450 |
---|---|---|---|---|---|---|---|---|---|
min | μM | pmol/min/pmol P450 | μL/min/pmol P450 | pmol P450/mg protein | μL/min/mg protein | % | |||
CYP2B6 | H3 | 10 | 2.13 | 0.737 | — | 0.346 | 39 | 13.5 | 25.5 |
H4 | 0.887 | 0.138 | — | 0.156 | 6.07 | 18.5 | |||
CYP2C9 | H3 | 30 | 28.8 | 0.0699 | — | 0.00243 | 96 | 0.233 | 0.440 |
H4 | 38.4 | 0.0564 | — | 0.00147 | 0.141 | 0.429 | |||
CYP2C19 | H3 | 10 | 1.59 | 0.735 | 2.13 | 0.461 | 19 | 8.76 | 16.5 |
H4 | 1.92 | 0.864 | 1.95 | 0.451 | 8.57 | 26.1 | |||
CYP2D6 | H3 | 10 | 77.0 | 0.977 | — | 0.0127 | 10 | 0.127 | 0.240 |
H4 | 44.3 | 1.97 | — | 0.0444 | 0.444 | 1.35 | |||
CYP3A4 | H3 | 10 | 11.2 | 3.14 | — | 0.280 | 108 | 30.3 | 57.2 |
H4 | 15.5 | 2.53 | — | 0.163 | 17.6 | 53.5 | |||
CYP3A5 | H3 | 10 | 42.6 | 1.82 | — | 0.0427 | 1 | 0.0427 | 0.0807 |
H4 | 32.1 | 1.33 | — | 0.0413 | 0.0413 | 0.126 |
↵a Hill coefficient.