Effects of the monoclonal antibody to CYP2B6 and the selective chemical inhibitors for CYP2C9 (sulfaphenazole), CYP2C19 (omeprazole), and CYP3A (ketoconazole) on H3 and H4 formation by HLMs
| Inhibition Ratio (%) | ||
|---|---|---|
| H3 Formation | H4 Formation | |
| Anti-CYP2B6 | 58.7 | 45.7 |
| Omeprazole | 9.73 | 12.6 |
| Ketoconazole | 18.6 | 37.9 |