Parameter | Control Rats | HFD-Fed Rats | Diabetic Rats |
---|---|---|---|
Rb1 (100 mg/kg p.o.) | |||
Rb1 | |||
AUC0–∞ (µg/ml⋅h) | 42.47 ± 7.26 | 35.61 ± 5.24 | 75.63 ± 12.10a |
Cmax (µg/ml) | 1.73 ± 0.25 | 1.20 ± 0.28 | 3.09 ± 0.34a |
tmax (h) | 8.80 ± 0.80 | 8.00 | 8.40 ± 0.40 |
t1/2 (h) | 24.00 ± 1.10 | 25.03 ± 1.66 | 20.08 ± 1.42 |
MRT (h) | 25.03 ± 0.54 | 27.01 ± 1.09 | 24.46 ± 0.94 |
F (%) | 0.90 | 0.78 | 2.25 |
CL (l/h per kilogram) | 2.38 ± 0.49 | 2.56 ± 0.40 | 1.37 ± 0.28 |
Rd | |||
AUC0–∞ (µg/ml⋅h) | 7.59 ± 2.25 | 2.40 ± 0.53 | 6.85 ± 0.88 |
Cmax (µg/ml) | 0.45 ± 0.08 | 0.21 ± 0.05a | 0.65 ± 0.07 |
tmax (h) | 8.80 ± 0.80 | 8.00 | 8.80 ± 0.49 |
t1/2 (h) | 16.78 ± 3.24 | 12.34 ± 3.21 | 9.27 ± 1.91 |
MRT (h) | 22.31 ± 2.71 | 18.18 ± 1.53 | 15.53 ± 1.71 |
Rb1 (10 mg/kg i.v.) | |||
Rb1 | |||
AUC0–∞ (µg/ml⋅h) | 472.3 ± 15.2 | 458.1 ± 22.0 | 335.6 ± 22.1b |
Vd (ml/kg) | 520.5 ± 15.9 | 523.9 ± 20.0 | 479.2 ± 17.5 |
t1/2 (h) | 18.19 ± 0.55 | 17.64 ± 1.00 | 11.26 ± 0.70b |
MRT (h) | 19.42 ± 0.32 | 19.50 ± 0.61 | 15.80 ± 0.93b |
CL (ml/h per kilogram) | 19.88 ± 0.67 | 20.80 ± 1.31 | 29.86 ± 2.26b |
Rd | |||
AUC0–72h (µg/ml⋅h) | 20.05 ± 6.14 | 10.67 ± 1.19 | 5.08 ± 0.35a |