BA type | Control | TAK-875 | |||||
---|---|---|---|---|---|---|---|
No. | (ng/ml) | Predose | 1 hour Postdose | Fold | Predose | 1 hour Postdose | Fold |
1 | CAa | 32,508 ± 16,453 | 27,242 ± 16,670 | 0.870 ± 0.358 | 22,973 ± 10,926 | 74,797 ± 19,259 | 2.94 ± 0.50 |
2 | DCA | 2796 ± 1386 | 2650 ± 1140 | 0.985 ± 0.350 | 1891 ± 803 | 3308 ± 1050 | 1.85 ± 0.43 |
3 | UDCAa | 6654 ± 2715 | 5591 ± 2917 | 0.846 ± 0.295 | 5710 ± 2844 | 14,661 ± 4748 | 2.80 ± 0.67 |
4 | LCA | 33.7 ± 13.3 | 25.0 ± 5.1 | 0.798 ± 0.209 | 30.8 ± 12.3 | 25.6 ± 6.8 | 0.876 ± 0.155 |
5 | GCA | 1700 ± 780 | 1156 ± 614 | 0.713 ± 0.298 | 1148 ± 1035 | 1335 ± 1119 | 1.30 ± 0.70 |
6 | CDCA | 4355 ± 863 | 3590 ± 1188 | 0.923 ± 0.450 | 4946 ± 2988 | 5633 ± 3218 | 1.24 ± 0.35 |
7 | GDCA | 415 ± 167 | 303 ± 141 | 0.742 ± 0.198 | 270 ± 151 | 269 ± 177 | 1.02 ± 0.45 |
8 | GCDCA | 127 ± 57 | 94 ± 47 | 0.794 ± 0.301 | 139 ± 83 | 181 ± 106 | 1.43 ± 0.71 |
9 | GUDCA | 471 ± 201 | 362 ± 286 | 0.754 ± 0.337 | 330 ± 192 | 404 ± 232 | 1.46 ± 0.82 |
10 | TCDCAa | 79 ± 24 | 110 ± 35 | 1.40 ± 0.31 | 99 ± 40 | 281 ± 137 | 2.87 ± 0.62 |
11 | TCAa | 238 ± 105 | 337 ± 137 | 1.45 ± 0.33 | 289 ± 175 | 635 ± 274 | 2.17 ± 0.85 |
↵a Indicates >2-fold increase at 1 hour postdose compared with the predose.